1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER

1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER - Names and Identifiers

Name	1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
Synonyms	1-Methyl-5-(4 AKOS BRN-1159 2-dioxaborolan-2-yl)-1H-indole 1-Methyl-5-indoleboronic acid pinacol ester 1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER 1-Methyl-5-(4,4,5,5-tetramethyl-1,2,3-dioxaborolan-2-yl)-1H-indole 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 1-Methyl-5-indoleboronic acid pinacol ester, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
CAS	837392-62-8
EINECS	1592732-453-0
InChI	InChI=1/C15H20BNO2/c1-14(2)15(3,4)19-16(18-14)12-6-7-13-11(10-12)8-9-17(13)5/h6-10H,1-5H3

1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER - Physico-chemical Properties

Molecular Formula	C15H20BNO2
Molar Mass	257.14
Density	1.05±0.1 g/cm3(Predicted)
Melting Point	110-114 °C (lit.)
Boling Point	391.3±15.0 °C(Predicted)
Flash Point	190.466°C
Vapor Presure	0mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.534

1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
Hazard Note	Irritant

1-METHYLINDOLE-5-BORONIC ACID, PINACOL ESTER - Introduction

1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is an organic compound with the chemical formula C15H19BO2N. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is a colorless or light yellow solid.
-Melting point: Its melting point range is about 70-75°C.
-Solubility: Soluble in some organic solvents, such as chloroform, ethanol, etc.

Use:
- 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is an important organic synthesis intermediate, commonly used in organic synthesis reactions.
-It can be used to construct a fused indole ring structure to synthesize biologically active compounds, such as drugs and pesticides.

Preparation Method:
1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole can be prepared in many ways, one of which is commonly used:
-First, 1-methylindole is reacted with boronic acid diphenyl ester under alkaline conditions to obtain boronic acid methylindole ester.
-Then, the ester group in the boronic acid methyl indole ester is replaced with tetramethylborate (such as tetramethylborate) to obtain 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole.

Safety Information:

Last Update：2024-04-09 21:01:54